As the name implies, the beads are shaped like tiny marbles, and glass hard. In my experience, they did not cause slow leaks, but instant loss of all air, till flat, same as lodging a toothpick into the air valve. If you have an air hose handy, you simply blow some air into the valve stem to dislodge the tiny bead and the valve will snap closed again. But if you do not have an air hose hand, all you can doo is listen to the tire go flat. So if you run those beads, anytime you decide to manually check/add air pressure, be sure to have. source of pressured air nearby.
I am not convinced there is a need for beads, weights, or centramatics. I ran the last DriveGuard throughout its 23,000+ life without anything, and could not tell any difference from the prior tire, which had the beads. Ditto for the front tire (BT45). I do not plan to ever use anything to, "balance" the tires on this GW again. JMHO