I-29 is closed from southern border of Iowa to Sioux City. There are a few spots you can still get through but you best bet is to find state or county roads that parallel I-29. If you ride the Iowa side, go thru the Loess Hills, decent roads and great views... Good luck
My relatives traveled from Nebraska into Iowa this week and said they had to drive all the way up to to Sioux City to be able to drive into Iowa. So it sounds like the only way in from the west is Highway 20.