Road Runner magazine did a "shamrock tour" (four tours) around Harrisburg each one around 200 miles. One is NE, SE, SW & W of Harrisburg. They used Harrisburg as the hub so you don't have pack/unpack everyday.
Didn't know if there was any quaint places to stay or motels someone has had good experience with, especially with motorcycles. Doesn't have to be Harrisburg proper.