No place is a perfect location for the whole country. However, Panama City Beach Florida is about 350 miles from the entire southeastern part of the country and portions of the midwest as well as south central. If I were to begin putting together an overnighter in March in Panama City Beach, Florida, would you come? It would likely be a Saturday into a Sunday. IF so, I will begin scouting out a restaurant and a hotel, pefrect for lizard activities.